Dopaminergic Neurons

XCell derives midbrain dopaminergic neurons using a two step protocol to reduce potential contamination from sympathetic adrenergic neurons and cortical dopaminergic neurons which are common contaminants in the direct differentiation process. After biasing NSC production to a midbrain phenotype, dopaminergic neurons are generated using a standardized protocol which gives us 30% or great dopaminergic neurons. Cells are supplied as a mixed population of neurons and glial precursors as this allows long-term maintenance of the cells in culture  (as long as a 100 days) and develop spiking activity that is characteristic of mature dopaminergic neurons.  Our dopaminergic neurons are supplied as a progenitor population to enable plating in a variety of formats including 96 well plates to ensure  consistency in  screening  experiments. Purified dopaminergic neurons can be supplied as a custom request. We can also derive dopaminergic neurons from any of the iPSC lines listed in our catalogue or from your line as a custom order.